CARNITINE for Polios
Polio 2000 Conference Melbourne 21/1/00 Tessa JUPP RN Dr John NIBLETT FRCR FRACR
Polio Clinic - Western Australia
ALERT - The health of your children and grand-children may also be at risk because you had Polio
We have always been told that polio, as an infectious disease, cannot be passed on to our children. Findings by the WA Polio Clinic indicate, - not that the polio can be passed on, but . . . that some of the problems we know as the Late Effects of Polio, can and may be affecting a number of our descendants.
This was brought to our attention a few
years ago by some of our members who were doing well on carnitine supplementation
themselves, so thought
they would try it on a son or daughter who was tired all the time and maybe had muscle pain too.
Carnitine seemed to help their children also. When we started to do blood carnitine levels on the children of polio survivors with these problems, we found that their levels were often even worse than the levels of their polio parent and grandchildren even lower again!
Low carnitine levels in muscle and blood give
* MUSCLE WEAKNESS
* MUSCLE PAIN
* LACK of ENDURANCE
So does POST POLIO SYNDROME!
Is this a coincidence or not?
At the Polio Clinic in Western Australia,
we have been investigating carnitine in conjunction with post polio since
1994. We have been looking at carnitine levels in the blood since
1996. We have found that often polio survivors have levels in the
of normal or below normal. Over 250 WA polio survivors have found an improvement in symptoms
ie much less fatigue, pain; and more strength, stability and endurance, when they take a carnitine supplement and eat more red meat, ie every day. We have noted that when people feel better, their carnitine blood levels are now at the top of the normal range.
· Research on post polio muscle biopsies
by Borg and Grimsby in Sweden and Dalakas in USA show that as a result
of polio, there is a greater number of type 1 muscles in polio survivors,
and that a number of these are previously type 2 muscles, changed to type
1 by surviving type 1 nerves as a result of sprouting during the recovery
process after polio.
Type 1 muscles use carnitine as the catalyst to produce energy from protein (animal) foods. More energy is available to type 1 muscle this way than with carbohydrate (plant) foods. Type 2 muscles do well with plant foods. We need a mixture of both sorts of foods so that both types of muscle can work well.
Carnitine is an amino acid (ie part of protein) that is found in our diet, primarily in red meat. Avocado is the only vegetable source that gives much carnitine.
FOOD SOURCES of CARNITINE
FOOD mg/100g of food
* avocado ? 100.0
* sheep 78.0
* beef 64.0
* pork 30.0
* chicken 7.5
* milk 3.4
* pear 2.9
* rice 1.8
* orange juice 1.3
* eggs 0.8
Our bodies make 25% of our carnitine requirements. The other 75% we should get from our diet. We have found that the amount often needed by polio survivors is the equivalent of from 1 kg - 5 kg of steak per day, an amount impossible to eat, so supplementation is the only other answer ie 500mg - 2500mg. This is best taken as a single dose as soon as you get up in the morning. An extra 250mg can be taken immediately prior to more strenuous activity if needed, eg golf, physio, hydrotherapy, shopping etc (if these normally wear you out.)
It is recommended that you work out your necessary dose by increasing by 250 mg every 3 days until your bowels get very loose. That will indicate too much so go back by the last 250 mg to get your effective dose. Below your dose you may still be tired. Carnitine is available in capsule or powder form. A flat 1ml scoop gives 500 mg. Powder should be a fine soft powder not a crystalline sparkling powder. We have found the crystalline powder to be less effective.
The action of carnitine is to transport
long-chain fatty acids (the breakdown of protein food) across the mitochondrial
membrane in muscle cells, to undergo the final breakdown into energy for
muscles. If you or your children are often tired and may have muscle
pain, try some carnitine. You may be surprised.